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KMID : 0043320120350071153
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Archives of Pharmacal Research
2012 Volume.35 No. 7 p.1153 ~ p.1158
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Sesquiterpenoids from Farfugium japonicum and their inhibitory activity on NO production in RAW264.7 cells
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Zhao Jiang He
Shen Tong
Yang Xia
Zhao Hong
Li Xia
Xie Wei Dong
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Abstract
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A new eremophilane sesquiterpenoid, namely, 3β-angeloyloxy-6β,8β-dihydroxy-9β-senecioyloxyeremophil-7(11)-en-12,8α-lactone, along with eight known sesquiterpenoids, was isolated from the rhizome of Farfugium japonicum. The structures of all isolates were identified based on analyses of spectroscopic data (HRESIMS, IR, 1D, and 2D NMR) and comparison with literature data. The inhibitory effects of compounds 1?4 on nitric oxide production in lipopolysaccaride-activated mouse macrophages were also evaluated.
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KEYWORD
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Farfugium japonicum, Sesquiterpenoid, Eremophilane, Lactone, Nitric oxide
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